Changes of serum ischemia modified albumin and high sensitivity C-reactive protein in patients with coronary heart disease after percutaneous coronary intervention and its clinical significance

Abstract

Objective To observe the changes of ischemia modified albumin(IMA), high-sensitivity C-reactive protein (hs-CRP) after percutaneous coronary intervention (PCI). The factors related to intervention procedures to patients with IMA and hs-CRP elevation after PCI and impact of the risk of IMA and hs-CRP on the clinical outcomes were investigated. Methods IMA, hs-CRP from vein blood of 90 cases received PCI were detected before operation and after operation at time of 30 min, 2h, 6h and 24h.The clinical characteristics of patients and factors related to intervention procedures were recorded.The number of lesion vessels and the relative factors in PCI were compared.The clinical outcomes of the patients were followed up. Results After operation, IMA was significantly different compared with that before operation (t=2.293, P<0.05). The concentration of IMA peaked at 2h after operation, which was significantly different from that before surgery (t=1.116, P<0.01). The increase of IMA and hs-CRP were closely related with the inflation pressure, total times of inflation, dilated times, length and diameter of stent and the number of stents (t=3.678, P<0.01). The angina onset was more common and length of stay was longer in the patients with the rise of IMA and hs-CRP. Conclusion PCI may cause myocardial injury, which is associated to inflation pressure, total time of inflation, dilated times, length and diameter of stent and the number of stents.To a certain extent the level of troponin can predict the outcomes. Key words: Angioplasty, transluminal, pevcutaneous coronary; Ischemia modified albumin; C-reactive protein; Myocardial ischemia