Abstract

Objective To evaluate the impact of thrombus-aspiration on ischemia modified albumin(IMA) during emergency percutaneous coronary intervention(PCI)in patients with acute ST segment elevation myocardial infarction(STEMI).Methods The STEMI patients underwent emergent PCI from May 2009 to August 2010,45 patients received aspiration thrombectomy were enrolled in study group,and those 47 patients who only received routine PCI were enrolled in control group. The clinical data,information after operation and the IMA、brain natriuretic peptides(BNP) and creatine kinase isoenzyme-MB(CK-MB) were compared between the two groups.Results IMA levels were elevated 30 minutes after PCI (P＜0.05),compared with control group,thrombus aspiration group had lower serum IMA level; They were decreased to the levels before PCI in 3 hours.The BNP levels were raised after PCI,The CK-MB level were raised the peak value in 12 h after PCI;The study group had lower serum CK-MB and BNP level.Conclusions IMA is a sensitive marker of myocardial ischemia,thrombus-aspiration could improve myocardium perfusion and reduce myocardial necrosis. Key words: ST segment elevation myocardial infarction(STEMI); Thrombus-aspiration; Ischemia modified albumin(IMA); Brain natriuretic peptides

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