Biogenic synthesis of gold nanoparticles using red seaweed Champia parvula and its anti-oxidant and anticarcinogenic activity on lung cancer

Abstract

The biocompatible gold nanoparticles (AuNPs) have great potential in the development of next-generation anti-cancer medicine. Here, AuNPs were synthesized through a biogenic method using the red marine algae Champia parvula. The synthesized Cp-AuNPs were characterized and confirmed by various spectroscopic techniques. The UV spectroscopy analysis found the Cp-AuNPs Surface Plasmon Resonance (SPR) peak at 550 nm. The accurate size and morphology of Cp-AuNPs were identified by Transmission Electron Microscope (TEM) and Scanning Electron Microscope (SEM) analysis were found to be 20 nm in size and round in shape. The crystal nature of Cp-AuNPs was confirmed by X-ray Diffraction (XRD) spectrum. The FTIR analytical tool was used to determine the presence of organic compounds in the algae extract and synthesized Cp-AuNPs. The biogenic Cp-AuNPs showed excellent anti-oxidant and free radical scavenging ability due to the presence of anti-oxidant-rich components. Anti-cancer activity of Cp-AuNPs was investigated on lung cancer (A549) cells and demonstrated high anti-cancer potential. Our findings suggested that synthesized Cp-AuNPs have a significant therapeutic ability for lung cancer.