Biogenic synthesis of gold nanoparticles using Jasminum auriculatum leaf extract and their catalytic, antimicrobial and anticancer activities

Abstract

Usage of plant sources for the biogenic synthesis of metal nanoparticles is an innovative area in modern nanotechnology research. In the present article, we have reported a trouble-free, environmentally benign approach for the biogenic synthesis of gold nanoparticles (Au NPs) using the Jasminum auriculatum leaf extract, which acts as a stabilising and reducing agents. The surface plasmon resonance peak at 547 nm in the UV–Visible absorption spectrum confirmed the biogenic Au NPs synthesis. TEM & SEM analysis revealed that the biogenic Au NPs are spherical with an average size of 8–37 nm. The catalytic reduction activity on p-nitrophenol revealed that the biogenic Au NPs are a versatile candidate for heterogeneous catalysis. The pH stability study using phosphate buffer solution confirmed the compatibility of our gold nanoparticles for biomedical applications. The cytotoxicity of the biogenic Au NPs revealed that the nanoparticles manifested a significant dose-dependent inhibitory effect in the proliferation of the human cervical cancer cell line with the IC50 value of 104 μg/ml. The biogenic gold nanoparticles showed tremendous antimicrobial commotion against human pathogenic bacteria (Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia) and fungus (Candida albicans, Aspergillus fumigatus, Lecanicillium lecanii and Trichoderma viride).