Abstract
Indole compounds are important class of therapeutic molecules, which have excellent pharmaceutical applications. The objective of present research was to investigate the influence of biofield treatment on physical and thermal properties of indole. The study was performed in two groups (control and treated). The control group remained as untreated, and biofield treatment was given to treated group. The control and treated samples were characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR) spectroscopy and ultraviolet-visible (UV-Vis) spectroscopy. XRD study demonstrated the increase in crystalline nature of treated indole as compared to control. Additionally, the treated indole showed increase in crystallite size by 2.53% as compared to control. DSC analysis of treated indole (54.45oC) showed no significant change in melting temperature (Tm) in comparison with control sample (54.76oC). A significant increase in latent heat of fusion (ΔH) by 30.86% was observed in treated indole with respect to control. Derivative thermogravimetry (DTG) of treated indole showed elevation in maximum thermal decomposition temperature (Tmax) 166.49oC as compared to control (163.37oC). This was due to increase in thermal stability of indole after biofield treatment. FT-IR analysis of treated indole showed increase in frequency of N-H stretching vibrational peak by 6 cm-1 as compared to control sample. UV spectroscopy analysis showed no alteration in absorption wavelength (λmax) of treated indole with respect to control. The present study showed that biofield has substantially affected the physical and thermal nature of indole.
Highlights
The theoretical basis of medicinal chemistry has become much more sophisticated, but is naive to suppose that the discovery of drugs is merely a matter of structure-activity relationships
The crystallite size was increased by 2.53% as compared to control indole
It is assumed that biofield treatment may cause decrease in nuclear density that led to increase in crystallite size
Summary
The theoretical basis of medicinal chemistry has become much more sophisticated, but is naive to suppose that the discovery of drugs is merely a matter of structure-activity relationships. Indole is organic compound which is parent substance for a large number of important molecules occurring in nature [1]. The indole based compounds are important class of therapeutic molecules which can replace many existing pharmaceuticals in near future. Tryptophan is an indole derivative which is one of the important amino acids. Serotonin an important indole derivative which is a vasoconstrictor hormone plays an interesting role in conducting impulses to brain [2]. Delavirdine and inhibitor of cytochrome P450 isozyme CYP3A4, is a drug which has been designed for HIV treatment [6]. Indole-3-carbinol (I3C) is a natural indole derivative found commonly in cruciferous vegetables which has been indicated as a promising agent in preventing breast cancer development and progression [7]
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