Associations of the fatty acids with the concentration of antioxidant enzymes in the blood in men with coronary heart disease

Abstract

Background and Aims : Objective: to identify associations of fatty acids (FAs) with the antioxidant enzymes in the blood of men with coronary heart disease (CHD).Methods: The study included: control group – 20 men without CHD, core group – 60 men with CHD. The core group was divided into subgroups: subgroup I – with the presence of vulnerable atherosclerotic plaques, subgroup II – with the absence of vulnerable atherosclerotic plaques. The levels of FAs, free radicals, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were analyzed in the blood.Results: In patients with CHD, compared with the control group: 1) were higher in the levels of SOD, CAT, myristic, palmitic, palmitoleic and octadecenoic FAs; 2) were lower in the levels of GPx, α-linolenic, docosapentaenoic, docosahexaenoic and arachidonic FAs. In subgroup I were found: 1) negative associations of SOD – with linoleic, eicosatrienoic, arachidonic, eicosapentaenoic, docosapentaenoic and docosahexaenoic FAs, positive associations – with palmitic acid; 2) positive correlations of CAT level with palmitoleic and stearic acids; 3) negative associations between of GPx and palmitic, palmitoleic, stearic and octadecenoic FAs. In subgroup II, the results of the correlation analysis were markedly different.Conclusions: Changes in the levels of antioxidant enzymes, and a disbalance of the FAs profile, probably indicate active oxidative processes in the body and may indicate the presence of atherosclerotic changes in the vessels. The study was conducted within the framework of: budget topic under State Task No. AAAA–A17-117112850280-2, with the support of bioresource collections; financial support from the Government of the Novosibirsk Region. Background and Aims : Objective: to identify associations of fatty acids (FAs) with the antioxidant enzymes in the blood of men with coronary heart disease (CHD). Methods: The study included: control group – 20 men without CHD, core group – 60 men with CHD. The core group was divided into subgroups: subgroup I – with the presence of vulnerable atherosclerotic plaques, subgroup II – with the absence of vulnerable atherosclerotic plaques. The levels of FAs, free radicals, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were analyzed in the blood. Results: In patients with CHD, compared with the control group: 1) were higher in the levels of SOD, CAT, myristic, palmitic, palmitoleic and octadecenoic FAs; 2) were lower in the levels of GPx, α-linolenic, docosapentaenoic, docosahexaenoic and arachidonic FAs. In subgroup I were found: 1) negative associations of SOD – with linoleic, eicosatrienoic, arachidonic, eicosapentaenoic, docosapentaenoic and docosahexaenoic FAs, positive associations – with palmitic acid; 2) positive correlations of CAT level with palmitoleic and stearic acids; 3) negative associations between of GPx and palmitic, palmitoleic, stearic and octadecenoic FAs. In subgroup II, the results of the correlation analysis were markedly different. Conclusions: Changes in the levels of antioxidant enzymes, and a disbalance of the FAs profile, probably indicate active oxidative processes in the body and may indicate the presence of atherosclerotic changes in the vessels. The study was conducted within the framework of: budget topic under State Task No. AAAA–A17-117112850280-2, with the support of bioresource collections; financial support from the Government of the Novosibirsk Region.