Assessment of serum estradiol effect on cervical cytomorphological changes in infertile women undergoing IVF/ICSI

Abstract

Women undergoing IVF procedures tend to have high levels of estradiol hormone because of the drugs used to stimulate egg production, and this may lead to display cervical cytomorphological changes & may affects pregnancy outcome in IVF cycles. The aim of the study is to correlate serum estradiol level on preovulatory day in women undergoing IVF/ICSI with cytomorphological changes in cervix and pregnancy test result. In this prospective case-control study, a total 100 cases were included 50 case group and 50 control group both in age range between (20-44) First blood sample to test serum estradiol taken on day 2 of menstrual cycle in both groups and second blood sample taken in preovulatory in both case and control group. Serum estradiol measured by Minividas. Cervical pap smear taken in preovulatory day in both case and control groups and stained with conventional pap stain then assessed according to Bethesda system 2001. There is non-significant correlation between serum estradiol in preovulatory day and appearance of abnormality in pap smear reports (P value=0.9). There is non-significant correlation between serum estradiol in preovulatory day and pregnancy test result (P value =0.5). In conclusion, serum estradiol does not have an association with IVF outcome and does not affect pap smear outcome.