Assessment of cervical cytomorphological changes in infertile women undergoing IVF/ICSI

Abstract

The aim of this study is to assess cervical cytomormophological changes in cervical smears taken from infertile women undergoing IVF/ICSI compared with normal fertile women. A case-control study of 100 cases were included, 50 infertile group and 50 normal fertile control group both in age range between (20-44), Pap smear taken prior to ova pickup in case group and in preovulatory day in control group. The mean age for case group was 28.9 ±5.6 year; and the mean age of control group was 29.7 ±5.5 years with no significant difference between them t=1.99, p=0.5, the most frequent cause of infertility is polycystic ovaries or with polycystic ovarian syndrome which diagnosed in (36%) of patients then (28%) of patients diagnosed with unexplained infertility. Case group has (22%) diagnosed with atypical squamous cells with undetermined significance (ASC-US) while control group has just 1 case (2%) with ASC-US and this affects pregnancy test result since (18%) out of (22%) of patient with (ASC-US) pap smear report has negative pregnancy test. Statistical analysis shows significant correlation between positive cervicitis and negative pregnancy test (P value = 0.04) because (52%) out of (66%) with positive cervicitis has negative pregnancy test.beside a significant relation between positive infection in pap smear report and negative pregnancy test because (30%) out of (34%) with positive infection in pap smear has negative pregnancy test. In Conclusions, infertile women eligible for IVF are more probable to have ASC-US when compared with normal fertile women, ASC-US worsen pregnancy test results in women undergoing IVF/ICSI because (18%) out of (22%) of patient with (ASC-US) have negative pregnancy test.