Assessment of insulin sensitivity and resistance in non diabetic Punjabi population

Abstract

Introduction: The pathogenesis of type 2 diabetes mellitus has been closely associated with dysfunctions observed in Insulin formation and pancreatic b cell functioning. Hepatic glucose output and insulin secretion from fasting levels of glucose and insulin have been widely validated clinically and epidemiologically to form a mathematical tool for estimating insulin resistance and b cell function. The tool has been named as the homeostasis Model Assessment tool (HOMA) and QUICK I index. The present study was designed to evaluate various biochemical parameters in two insulin resistance groups established by cutoffs of HOMA index and QUICK I. Materials and Methods: Total 5 00 non diabetic subjects attending the out-patient department of Sri Guru Ram Das Institute Of Medical Sciences and research Vallah, Sri Amritsar were included in the present study. After excluding 23 persons having HBA1C > 7 % we were left with 477 subjects. They were analyzed for Fasting Blood Glucose, HBA1C, S. Insulin and Lipid Profile. HOMA-IR index and QUICK I index were calculated using formulas. On the basis of the cutoffs of the above indices, the non diabetic persons were divided into High and Low insulin resistance groups. Results: Prevalence of insulin resistance in non diabetic general population was 41.5 % as estimated by cutoffs established by QUICK I index. It was much lower when HOMA IR index was used. Conclusion: Quick I is the more sensitive index as compared to HOMA IR for the screening of Insulin resistance. Moreover, the amount of adipose tissue is the risk factor for Insulin resistance and not the sex. Keywords: Insulin Resistance, QUICK I, Modified QUICK I, HOMA Ir.