Risk factors of metabolic syndrome and insulin resistance in type 2 diabetic patients

Abstract

Objective To investigate the risk factors of insulin resistance (IR) and metabolic syndrome (MS) in type 2 diabetic patients. Methods Total 373 type 2 diabetic patients were enrolled from Beijing Anzhen and Cuigezhuang communities, and classified as non-MS and MS based on the criteria of Chinese Diabetes Society. Islet function was measured, and correlation analysis was carried out on two indexes HOMA-IR and HOMA-β among patients with different MS components. Results Among 373 T2DM patients, 255 (68.3%) cases were MS T2DM and 118 (31.7%) were non-MS T2DM. The diabetic patients with MS had higher body mass index(27.21 vs. 23.84, P<0.001)and HOMA-IR(3.3 vs. 2.2, P<0.001), and increased waist circumference, neck circumference, triglyceride, uric acid, and HOMA-β, compared to none of MS diabetic patients(all P<0.05). The high density lipoprotein level in the diabetes patients. with MS was lower than that in non-MS diabetic patients(P<0.05). HOMA-IR was increased with the increasing numbers of MS components. Spearman analysis showed that the numbers of MS components were positively correlated with HOMA-IR and HOMA-β (r=0.238, 0.124, respectively, all P<0.01). Conclusions Diabetic patients with MS have higher body mass index, triglyceride, uric acid and IR, compared to non-MS patients.With the increasing numbers of MS components, insulin resistance becomes more prominent in diabetic patients.The results suggest that comprehensive management of insulin resistance-related factors should be strengthened in addition to blood glucose control in community health service. Key words: Diabetes mellitus, type 2; Metabolic syndrome X; Insulin resistance