Correlation among Ang-(1-7), AngII/Ang-(1-7), insulin resistance and lipid metabolism in peripheral blood of polycystic ovary syndrome patients

Abstract

Objective To investigate the correlation among renin angiotensin system (RAS), insulin resistance (IR) and lipid metabolism in polycystic ovary syndrome (PCOS) patients. Methods According to homeostasis model assessment (HOMA)-IR, PCOS patients were divided into IR group (HOMA-IR≥2.69, n=80) and non-IR (NIR) group (HOMA-IR<2.69, n=67), 25 women with normal menstrual cycle were selected as the control. The levels of plasma AngⅡand Ang-(1-7) were examined by enzyme-linked immunosorbent assay (ELISA); serum sexual hormone, fasting insulin (FINS), serum glucose and lipid were examined by chemiluminescence method. Results 1) The levels of AngⅡand Ang-(1-7) in IR and NIR group were all higher than those in the control (P 0.05), but the level of Ang-(1-7) was lower in IR group than in NIR group (P 0.05). 3) Pearson correlation analysis showed that Ang-(1-7) was negatively correlated with FINS, HOMA-IR, and body mass index (BMI) in IR group, and showed a positive correlation with follicle stimulating hormone (FSH) (P<0.05); Ang-(1-7) in NIR group was negatively correlated with triglyceride (TG), and had a positive correlation with high density lipoprotein (HDL) (P<0.05). Conclusion A hyperthyroidism phenomenon of AngⅡ and Ang-(1-7) levels exists in PCOS women as compared with the control. The imbalance of Ang Ⅱ/ Ang-(1-7) is associated with IR and metabolic disorders in PCOS patients. IR and metabolic disorders may be improved by improving Ang-(1-7) level. Key words: Polycystic ovary syndrome (PCOS); Angiotensin Ⅱ(Ang Ⅱ); Angiotensin 1-7 [Ang-(1-7)]; Insulin resistance (IR); Obesity