Assessing Genders Separately in Nondiabetic Persons Regarding Links Between Insulin Resistance and Fat Mass With Elements Related to the Metabolic Syndrome

Abstract

Objective Initial results gathered from previously published observations dealing with nondiabetic volunteers reveal that both the fasting blood glucose (FBG) level employed as a surrogate for insulin resistance (IR) and the amount of body fat mass (FM) correlate significantly with the strength and pathological direction of many harmful elements making up the metabolic syndrome (MS). These initial results were obtained using combined data from both females and males. How the two markers correlate with specific metabolic parameters in each gender separately was not established. Method Baseline data from more than 700 volunteers were examined mainly using correlations to compare whether the breadth of IR estimated by FBG levels and/or the accumulation of body FM on the early development and progression of many chronic metabolic derangements differ to any meaningful extent between nondiabetic females and males. Results The following significant positive correlations were found in the data on females employing either FBG or FM as independent variables regarding development of elements associated with MS: in body composition (scale weight, fat free mass [FFM]); in blood chemistries (triglycerides, high-sensitivity C-reactive protein [hsCRP], alanine aminotransferase [ALT]); and in blood counts (white blood cells [WBC], neutrophils). Also consistent with MS, high-density lipoprotein cholesterol levels declined significantly. In males, findings with FBG as the independent variable differ from females in some respects. These major exceptions are lack of significant correlations with FFM and high-density lipoprotein cholesterol as well as a weaker link with ALT. Despite a positive hsCRP linkage, a poorer response of WBC and neutrophils appeared in males when correlations were made. The latter disassociations disappeared when FM replaced FBG as the independent variable. Conclusions Progression of many chronic metabolic derangements differ only slightly in females and males.