Correlation analysis of risk factors for atherosclerotic cerebral infarction combined with metabolic syndrome in elderly patients

Abstract

Objective To analyze the clinical features of metabolic syndrome (MS) combined with and cerebral infarction (ACI) in elderly patients, and to investigate the high-risk metabolic factors for MS combined with ACI in the elderly. Methods A total of 337 elderly patients admitted to general internal medicine wards of our hospital from 2013 to 2015 were divided into MS combined with ACI group (group A), MS group (group B), ACI group (group C) and control group (group D, patients with non-MS and non-ACI). Age, smoking history and past history were recorded. The systolic blood pressure (SBP), diastolic blood pressure (DBP), levels of fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), serum creatinine (CRE), glycated hemoglobin (HbA1c), glycosylated serum protein (GSP), uric acid (UA), homocysteinemia (HCY), fasting serum insulin, serum C-peptide, D-dimer (DD) were detected. Body mass index (BMI) and insulin resistance index (HOMA-IRI) were calculated. Results Age, levels of FBG, GSP, TG, systolic blood pressure, HCY, DD and HOMA-IRI were higher and the HDL-C level was lower in group A than in group B (all P <0.05). Age, levels of FBG, HbA1c, GSP, TG, TC, LDL-C, HCY, DD and HOMA-IRI were higher in group C than in group D (all P <0.05). Multivariate Logistic regression analysis showed that age (≥75 years), hypertension (blood pressure ≥140 / 90mmHg), high FBG (≥7.0 mmol/L), high TG (≥1.7 mmol/L), low HDL-C (<0.9 mmol/L), high HCY (≥20.4 μmol/L) and a history of smoking or increased carotid artery intima-media thickness (CA-IMT) were the independent risk factors for atherosclerotic cerebral infarction combined with MS (OR= 5.233, 2.870, 3.138, 5.184, 3.375, 4.545, 3.809, 3.663, respectively, all P<0.05). Conclusions Atherosclerotic cerebral infarction are affected by multiple metabolic abnormalities of MS in elderly patients. Age over 75 years, high blood pressure, high fasting glucose, hypertriglyceridemia, low high-density lipoprotein cholesterol, high homocysteine and smoking history, increased carotid artery intima-media thickness are closely related to atherosclerotic cerebral infarction combined with MS in the elderly. Key words: Metabolic syndrome×; Brain infarction; Risk factors