Relationship between benign prostate hyperplasia and metabolic syndrome

Abstract

Objective To investigate the risk factors of benign prostate hyperplasia (BPH). Methods A total of 738 male subjects were assigned to the non-BPH+ non-metabolic syndrome (MS) group (group A), BPH + non-MS group (group B), MS+ non-BPH group (group C), and BPH+ MS group (group D). Body mass index(BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glycosylated alanine aminotransferase (ALT), serum creatinine, hemoglobin (HbA1c), and serum uric acid (UA) were measured. Results In comparison with group A, age, BMI, SBP, DBP, TG, TC, LDL-C and HbA1c of group B were significantly increased, although HDL-C was significantly reduced.Age, BMI, SBP, DBP, TG, TC, LDL-C, UA and HbA1c of group D were significantly higher than those of group C, while HDL-C was relatively lower.In multivariate logistic regression analysis, >60 years [odds ratio (OR)=4.432, 95% confidence interval (CI) 1.331 to 14.759], overweight/obese (OR=228.165, 95% CI 21.932 to 2373.724), hypertension (OR=33.350, 95% CI 10.221 to 108.824), higher FBG (OR=131.669, 95% CI 21.033 to 824.279), and higher TG (OR=53.500, 95% CI 11.547 to 247.889) were independent risk factors of BPH with MS. Conclusion Our data suggest a close relationship between BPH and MS.Elderly, overweight/obesity, and higher blood pressure, TC or FBG might be the risk factors of BPH and MS. Key words: Prostatic hyperplasia; Metabolic syndrome X; Risk factors