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Abstract
Objective The purpose of this study was to assess the impact of bitter melon extract supplementation on glycemia in individuals with prediabetes. Methods This was a 12-week randomized, parallel, placebo-controlled study where 75 adults with prediabetes were randomly allocated into the low-dose bitter melon (300 mg/day) (n = 26), high-dose bitter melon (600 mg/day) (n = 24), or control (n = 25) groups. Results At baseline and weeks 6 and 12, anthropometrics were measured, and fasting blood samples were obtained. The high-dose (1.05% ± 10.2%) and low-dose bitter melon (3.35% ± 13.2%) groups showed smaller increases in blood glucose levels at 12 wk, compared to the control group (11.0% ± 16.3%) (p < 0.05). A subgroup analysis of participants with age ≥ the median demonstrated a greater reduction in glycated hemoglobin at 12 wk in the high-dose bitter melon group (median change: −0.20%; IQRL: −0.20%, −0.05%) vs. the control group (median change: 0.00%; IQRL: −0.10%, 0.20%) (p = 0.017). Compliance with the interventions was >95%, and the study products were tolerated well. Conclusion The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.
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