Abstract
Introduction. Cancers of the head and neck, which include neoplasia of the ENT or upper respiratory and digestive tracts, represent a wide variety of malignant diseases originating in the cells of the upper aerodigestive tract. Oropharyngeal carcinoma represents 10-15% of head and neck neoplasms. Objective of the study. The purpose of this paper is to review recent data on several topics, including HPV-positive risk factors for oral squamous cell carcinoma (OSCC), guidelines in diagnostic evaluation, treatment, prognosis and prevention strategies. The purpose of the paper. A comparison of proliferation factors, degradation of the basal lamina and modulation of the connective tissue with the survival time of patients diagnosed with oropharyngeal neoplasm. Materials and method. The study analyzed a group of 272 patients hospitalized in the ENT Clinic of the Craiova County Emergency Clinical Hospital over a period of five years, between 1 January 2017 and 31 December 2021, diagnosed with oropharyngeal neoplasm. Results. The present study included a number of 272 malignant oropharyngeal tumors, of which the majority were represented by squamous cell oropharyngeal carcinomas; well differentiated (19 cases; 6.99%), moderately differentiated (130 cases; 47.79%), poorly differentiated (110 cases; 40.44%); LMNH (four cases; 1.47%), one leiomyosarcoma (0.36%), one malignant synovioma (0.36%) and one adenoid cystic carcinoma (0.36%). Two patients refused biopsy (0.73%) and four patients preferred that the histopathological examination be performed in the private system as well (1.47%). Conclusions. Oropharyngeal squamous cell carcinoma accounts for 95% of all head and neck cancers, and in the last decade its incidence has increased by 50%.
Published Version
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