Abstract
The nutraceutical efficacy of phytochemical curcumin has been utilized in many therapeutic foods and drugs, thanks to their anti-inflammatory, antimicrobial, antioxidant, antitumor and anticancer activities. Therefore, it is necessary to develop green and scalable methods of isolating the natural products from the Curcuma longa plant. This study presents an environmentally friendly method of aqueous extraction to obtain fine curcumin powder with high purity (84.6 % quantified by HPLC). The fine curcumin combines with montmorillonite clay to synthesize an improved drug delivery vehicle. Synthetically, equilibrium adsorption of curcumin on montmorillonite results in a curcumin-loaded montmorillonite structure. The montmorillonite/ curcumin drug delivery vehicle shows good properties of aqueous dispersibility and curcumin stabilization in the environment of neutral water and natural/ ultraviolet lights. The innovative formulation of montmorillonite/curcumin helps to upgrade the bioavailability and stability of bioactive curcumin in nutraceutical delivery applications.
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