Application and effect of aerosol inhalation of isoprenaline on neonates with mechanical ventilation after air tube drawing

Abstract

Objective To explore the effect of aerosol inhalation of isoprenaline on neonates with mechanical ventilation after air tube drawing. Methods Ninety neonates with mechanical ventilation were randomized into observation group and control groups, each group comprised 45 cases respectively. After air tube drawing, in the control group, all the patients were treated with oxygen inhalation and anti-infection treatment, aerosol inhalation of ambroxol(30 mg)and dexamethasone(5 mg), based on the control group,observation group was added isoprenaline (0.25 mg)during inhalation each time, the improvement of breathing and local symptoms were observed. Results (1)Three-concave sign relieving time, laryngeal edema disappearing time and sputum vanishing time in the observation group〔(1.3±0.3)d,(2.1±0.6)d,(2.9±0.6)d,(4.2±0.9)d respectively〕were all less than those in the control group〔(1.9±0.4)d,(2.8±0.5)d,(3.7±0.5)d,(5.1±1.2)d respectively〕;success rate of removing mechanical ventilator in observational group(96.7%)was higher than that in the control group.(2)Airway injury rate in observation group(2.2%)was less than the control group(13.3%).(3)BP elevation and reflecting HR dropping were rarely seen in observational group. Conclusions Aerosol inhalation of isoprenaline allied with ambroxol& dexamethasone can obviously alleviate laryngeal edema and improve respiratory function, and increase success rate of removing rate of mechanical ventilator; meanwhile, facilitate nursing works. Key words: Tracheal intubation; Isoprenaline; Aerosol inhalation; Laryngeal edema; Nursing