Effect comparison of different aerosol inhalation methods of continuous non-invasive positive pressure ventilation in patients with AECOPD combined withII type respiratory failure

Abstract

Objective To compare the application effects of different aerosol inhalation methods of continuous non-invasive positive pressure ventilation (NIPPV) in the treatment of the patients with AECOPD combined withⅡ type respiratory failure and offer reference for the appropriate choice of patients' aerosol inhalation methods. Methods With the convenience sampling method, totals of 150 continuous NIPPV patients with AECOPD combined withⅡ type respiratory failure were divided into the observation group and the control group according to the hospitalization time (75 patients in each group) . The patients in the control group used NIPPV and the standard oral spray driven by the atomizing pump. In the observation group the aerosol inhalation device was connected between the nasal face mask/nasal mask and the pipeline of the breathing machine. The patients in the observation group used NIPPV combined with the inhalation of atomizing drugs. Patients' oxygen saturation, heart rate, respiratory rate, dyspnea, dry mouth and sore throat, expectoration difficulties and comfort level in the two groups were compared between before and after the aerosol inhalation. Results After the aerosol inhalation, the heart rate and the respiratory rate in the observation group were (98.32±3.39) times/min and (23.16±1.30) times/min respectively, which were significantly lower compared with the control group [heart rate: (100.18±3.16) times/min, t=3.476, P<0.05; respiration rate: (25.67±1.21) times/min, t=12.240, P<0.05].The scores of dry mouth and sore throat, expectoration difficulties, and the comfort level in the observation group were (17.53±2.73) , (20.49±3.71) and (17.81±4.47) , which were significantly higher compared with the control group [dry mouth and sore throat: (16.48±3.07) , t=2.213, P<0.05; expectoration difficulties: (14.43±2.18) , t=12.196, P<0.05; comfort level: (16.37±3.74) , t=2.140, P<0.05]. Conclusions In the process of the continuous NIPPV, the aerosol inhalation device and nasal face mask are connected in the pipeline of the non-invasive breathing machine for the aerosol inhalation treatment, which can improve the therapy effect and the comfort level for patients and decrease the adverse effect level due to the use of the breathing machine. Key words: Pulmonary disease, chronic obstructive; Aerosol inhalation; Non-invasive positive pressure ventilation