Abstract
In dragon fruit cultivation, stems that have been fruited must be pruned and discarded, because they cannot produce fruit again. If this is not used, it will become a waste. Therefore, in this study, it will be developed into an antimicrobial material, because the stems of red dragon fruit (Hylocereus polyrhizus) are known to have several antibacterial compounds. The purpose of this study was to determine the antibacterial activity of ethanol extract, n-hexane, ethyl acetate, and water fractions from dragon fruit stems on the growth of Methicillin-resistant Staphylococcus aureus (MRSA), and to determine the types of compounds that are antibacterial. The result shows that the data on the greatest antibacterial activity was found at a concentration of 30% both in the ethanol extract (1.850cm); n-hexane fraction (1.948 cm); ethyl acetate fraction (1.640 cm) and water fraction (0.884 cm). Meanwhile, the results of contact bioautography showed that the antibacterial compounds of Methicillin-resistant Staphylococcus aureus (MRSA) were flavonoids, saponins, and steroids. Thus, the presence of antibacterial compounds can be further investigated to be developed into topical antibacterial dosage form, as well as cosmetic preparations.
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