Abstract
Anthropometric correlates of morning plasma cortisol level and hormonal and biochemical response to fasting in obese premenopausal women
Highlights
Since the early observation of J.Vague [1], numerous studies have demonstrated that high waist-to-hip circumference ratio (WHR), an indicator of android or abdominal body fat distribution (BFD), is a predictor or risk factor of diabetes mellitus [2], cardiovascular diseases and their complications [3]
Increased cortisol responsiveness was observed in women with abdominal type of obesity after adrenal stimulation by physical and mental stress [13] but diminished cortisol response was found in oral glucose tolerance test in men [14]
We investigated a wide set of anthropometric variables in order to screen and choose specific signs, other than WHR, for the increased secretory patterns and metabolic stress responsiveness of adrenals as assessed by the morning plasma cortisol level
Summary
Since the early observation of J.Vague [1], numerous studies have demonstrated that high waist-to-hip circumference ratio (WHR), an indicator of android or abdominal body fat distribution (BFD), is a predictor or risk factor of diabetes mellitus [2], cardiovascular diseases and their complications [3]. The function of hypothalamic-pituitary-adrenal (HPA) axis was shown to be related to the type of BFD [8,9,10]. It is a wonder that in all these investigations the WHR and abdominal visceral-to-subcutaneous fat ratio [15] were the only examined somatometric indices [16] a priori being considered the most powerful predictors of HPA axis activity [17]
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