Analysis of the results of D-dimer and coagulation indicators in pregnant patients with hypertensive disorder

Abstract

Objective To analyze the clinical test results of D-dimer and coagulation indicators in pregnant patients with hypertensive disorder, and to explore the diagnostic value of D-dimer and coagulation index. Methods From January 2016 to December 2017, 50 pregnant women with hypertensive disorder (observation group) and 50 healthy pregnant women(control group) who underwent antenatal examination in the Traditional Chinese Medicine Hospital of Yiwu were selected.The plasma D-dimer, coagulation parameters (prothrombin time, activated partial thromboplastin time, thrombin time) were compared between the two groups.According to the condition of hypertensive disorder complicating pregnancy, the observation group was divided into three subgroups: simple gestational hypertension group, mild preeclampsia group and severe preeclampsia group.Pearson correlation coefficient analysis was used to analyze the correlation between plasma D-dimer, coagulation parameters and hypertensive disorder complicating pregnancy. Results In the observation group, the D-dimer level[(413.15±127.62)μg/L] was higher than that in the control group[(284.29±97.86)μg/L](t=5.666, P<0.05). The prothrombin time[(10.12±1.07)s], activated partial thrombin time[(25.16±3.32)s], and thrombin time[(20.87±2.52)s] in the observation group were all shorter than those in the control group[(12.54±1.93)s, (31.84±5.87)s, (24.26±3.27)s](t=7.754, 7.004, 5.806, all P<0.05). The differences of D-dimer level, prothrombin time, activated partial thrombin time and thrombin time among the simple gestational hypertension group, mild preeclampsia group and severe preeclampsia group were statistically significant(F=4.710, 4.297, 4.411, 4.979, all P<0.05). The level of D-dimer was positively correlated with hypertensive disorder complicating pregnancy(r=0.725), while prothrombin time, activated partial thromboplastin time and thrombin time were negatively correlated with hypertensive disorder during pregnancy(r=-0.713, -0.704, -0.719). Conclusion The blood of patients with hypertensive disorder complicating pregnancy is generally in hypercoagulable state of D-dimer.The detection of coagulation index can be used as an auxiliary diagnostic index for hypertensive disorder complicating pregnancy. Key words: Hypertension, pregnancy-Induced; Pregnancy complications; Eclampsia; D-dimer; Prothrombin time; Factor VIII; Thrombin time; Diagnosis