Different pregnancy coagulation indices variation and significance in pregnacy women

Abstract

Objective To explore coagulation indices clinical variation and significance of prothrombin time(PT).Activated partial thromboplastin time(APTT),Fibrinogen (Fg),thrombin time(TT) and fibrinogen/fibrin degradation products (FDP) during the different pregnacy. Methods By the ACL 7000 from the company of Americian BECKMAN COULTER,the samples of 200 women of early,Middle and late pregnancy and 50 unpregnant women were tested and the results were compared. Results PT,APTT,TT were apprently shortened in the middle and late pregnacy than that in controls,the difference was statistically significant (P＜0.05),Fg and FDP were obviously higher than that in controls,there were notable difference in APTT and Fg,Which was significantly different(P＜0.05). While PT,TT and FDP had no obvious difference,without statistical significance(P＞0.05). During the middle and later period of pregnancy,the indices of Fg and FDP rise remarkably,with statistical differences (P＜0.05),While PT,APTT and TT had no obvious changes,with no statistical significance(P＞0.05). Conclusions PT.APTT and TT can be used as selection indices of hemorrhage and thrombin diseases.As an inportant substrate in the course of coagulation,Fg has great correlation with the blobd kinetics and the aggregation of platelets.FDP indicates the general level of fibrinolytic activity.These five indices above are mainly able to guarantee the selection needs before an operation. Key words: Pregnancy ; Indices of thrombin ;