Abstract
The problem of antimicrobial resistance is one of the key challenges in the modern world. A global analysis of the resistance development to antibacterial drugs has shown that solving this problem requires designing of complex interdisciplinary approaches. Searching for tools that would prevent and suppress the development of antimicrobial resistance is an actual scientific task that has a clear practical orientation. Aim. To analyze modern approaches, to avoid the development of antibacterial drugs resistance and to determine the role of physicochemical research IN VITRO and IN VIVO (bioequivalence studies) in solving this problem. Results. While carrying out the research, we made a systematic analysis of modern international concepts, regulatory guidelines, recommendations and programs for a comprehensive solution to the global problem of antibiotic resistance. During this work, we identified the key areas directly related to the issues of proper pharmaceutical development and research of antibacterial drugs, as well as the introduction of new scientific approaches and procedures for preventing the resistance of these drugs. It has been found that physicochemical methods of analysis can be used for scientifically substantiated creation of regimens of sustainable antibiotic therapy, as well as biopharmaceutical modeling of interaction with other objects (drugs, mineral waters, drinks, etc.). Such tests are an additional tool for excluding the risk of mismatch evaluation when conducting an assessment of generic drugs both in the biowaiver procedure and in the study of bioequivalence. Conclusions. The analysis of modern approaches to prevent the development of antibacterial drugs resistance has shown that it is necessary to use comprehensive application of scientific methods when making a research of this problem. The developed classification of approaches to eliminate antimicrobial resistance highlights the methods of physicochemical and bioanalytical research as a promising tool to reduce the risk of antibiotic resistance.
Highlights
While carrying out the research, we made a systematic analysis of modern international concepts, regulatory guidelines, recommendations and programs for a comprehensive solution to the global problem of antibiotic resistance
We identified the key areas directly related to the issues of proper pharmaceutical development and research of antibacterial drugs, as well as the introduction of new scientific approaches and procedures for preventing the resistance of these drugs
It has been found that physicochemical methods of analysis can be used for scientifically substantiated creation of regimens of sustainable antibiotic therapy, as well as biopharmaceutical modeling of interaction with other objects
Summary
Analysis of the modern approaches for the prevention of antimicrobial resistance: role and place of physical and chemical research methods in vitro and the investigation of bioequivalence. The problem of antimicrobial resistance is one of the key challenges in the modern world. A global analysis of the resistance development to antibacterial drugs has shown that solving this problem requires designing of complex interdisciplinary approaches. Searching for tools that would prevent and suppress the development of antimicrobial resistance is an actual scientific task that has a clear practical orientation. Aim. To analyze modern approaches, to avoid the development of antibacterial drugs resistance and to determine the role of physicochemical research IN VITRO and IN VIVO (bioequivalence studies) in solving this problem
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