Abstract
Methods: The CNF investigation was performed by histochemical cholinesterase (CE) detection with alternative method by Crevier and Belanger in modification of Savay and Csillik. Results: On early terms of disease the CNF are presented by nerve bundleswith dense network of fine terminal fibrils ending on myocytes. Several CNF have different CE activity and look like dotted line. At the same time the lowCNF density area are observed. As the termof thedisease growth theCNFdensity decreases. Thefibers become thinner and truncated with deformations, fragmentations and decreasing of their color intensity. The nerve bundles take less space and become lighter, indicating the CE activity decreasing. However, in some areas the increased CNF density are observed that can be considered as a compensatory mechanisms signs. Conclusions: The analysis of the bladder cholinergic activity in perimenopausal women with OAB has showed the progressive parasympathetic denervation with a direct correlation with the term of disease.
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