Relationship between the activity of cholinesterase and the prognosis of patients with acute myocardial infarction

Abstract

Objective To study the relationship between the activity of cholinesterase and the prognosis of patients with acute myocardial infarction (AMI). Methods A total of 300 cases of AMI admitted to our hospital from January 2012 to January 2017 were enrolled in the study. According to the activity of cholinesterase, they were divided into group A (patients with low activity of cholinesterase,n=160) and group B (patients with high activity of cholinesterase,n=140). The prognosis and clinical indicators were compared between the two groups. Results There were no statistically significant differences between the two groups in smoking history, gender composition, hypertension, Killip grade, and HDL level (P>0.05). Age, serum creatinine, and mortality rate of group A were significantly higher than those of group B, BMI, systolic blood pressure, diastolic blood pressure, blood glucose, LDL, triglyceride, total cholesterol, and LVEF in group A were significantly lower than those in group B (P<0.05). The activity of cholinesterase was negatively correlated with age and serum creatinine, while was positively correlated with BMI, systolic blood pressure, diastolic blood pressure, blood glucose, LDL, triglyceride, total cholesterol, and LVEF (P<0.05). The main influencing factors of mortality were the decrease of the activity of cholinesterase and LVEF. Conclusion There is a correlation between the prognosis of AMI and the activity of cholinesterase. The main independent factor influencing mortality of patients is the activity of cholinesterase, and its determination can provide some guidance for the treatment of patients. Key words: Cholinesterase; Acute myocardial infarction; Prognosis; Relationship