Abstract
A murine model is used to study qualitatively and quantitatively the splenic ultrastructural changes induced by two Trypanosoma evansi strains derived from naturally infected local equine hosts (Equusasinus and E. caballus); T. evansi causes ultrastructural modifications in the spleen of the infected mice. The modifications include tissular disorganization, fibrosis, mitochondrial swelling, apoptosis and necrosis. The initial phases of the infection are quite similar, whereas the final phases differ qualitatively depending on the strain’s source. The ultrastructural quantitative changes were studied in the reticular splenocytes covering alterations in the area of the cytoplasm and nucleus. Analysis of the results shows the induction of various splenic alterations caused by local T. evansi strains. Also, it was documented that discriminative time modulation, as well as progressive tissular, cellular and subcellular changes, are more associated with derived infections from E. caballus strain.
Highlights
Trypanosoma evansi is the etiologic agent of equine trypanosomosis in the savannas of Venezuela
While there is some understanding about the ultrastructural pathology of the infections induced by local T. evansi isolates [1] [2] [3] [4], it should be noted that an important genetic [5] and parasitological [6] variability has been demonstrated in the behavior of different strains [6], nothing is known about its effects in the spleen, and much less still regarding the comparative action of two strains of equine origin upon this organ
The analysis demonstrated the significance of the change for each parasite isolate and the linearity of the nuclear area changes, which were faster in the animals infected with T. evansi isolate derived from E. caballus than that derived from E. asinus (Table 2)
Summary
Trypanosoma evansi is the etiologic agent of equine trypanosomosis in the savannas of Venezuela. While there is some understanding about the ultrastructural pathology of the infections induced by local T. evansi isolates [1] [2] [3] [4], it should be noted that an important genetic [5] and parasitological [6] variability has been demonstrated in the behavior of different strains [6], nothing is known about its effects in the spleen, and much less still regarding the comparative action of two strains of equine origin upon this organ. Studying the effects of an archetypal blood trypanosome upon this organ represents a significant contribution to the understanding of the biology of T. evansi
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