Ameliorate role of alpha lipoic acid on the beta amyloid accumulation and some serum oxidant / antioxidants levels in brain aging induced by d-gal in male rats

Abstract

Alpha lipoic acid has both hydrophilic and hydrophobic properties and is widely dispersed in cellular membranes and the cytoplasm. It is one of the most powerful antioxidants for cells. The current research looked at the possible therapeutic benefits of alpha lipoic acid) in a male rat model of D-galactose-induced brain aging. G1 normal as control group, G2 animals were given 200 mg/kg bw.IP. daily of D-gal group for 30 days, and G3 animals were given 100 mg/kg. G4 D-gal + alpha lipoic acid group200mg/kg bw.IP. daily with 100 mg/kg. IP every day for 30 days.The accumulation of Beta amyloid in the brain and changes in serum oxidant/antioxidant levels Increased levels of oxidative stress indicators our data demonstrate that the D-gal aging model causes an increase in brain Beta amyloid deposition, as well as a substantial rise in serum MDA, GSH, CAT, and SOD levels. To summarize, our research focused on the brain damage caused by D-gal, which can be mitigated by intubating 100 mg/kg B.W.IP. of ALA to counteract its negative effects.