Abstract
Abstract Aim: To determine the pattern of cytokine synthesis in the ascitic fluid (AF) of cirrhotic patients, with or without spontaneous bacterial peritonitis (SBP). Patients and methods: We
Highlights
There is increasingly evidence that several cytokines mediate hepatic inflammation, apoptosis and necrosis of liver cells, chollestasis and fibrosis
Ascitic levels of IL-10, IL-6, IL-1ra, TNF-a, STNFRII and STNFRI were higher in ascitic fluid of patients with bacterial ascites, while TGF-b1 levels were lower in the ascitic fluid of patients with spontaneous bacterial peritonitis (SBP)
It is remarkable that IL-1b was not expressed in patients either with or without spontaneous bacterial peritonitis SBP
Summary
There is increasingly evidence that several cytokines mediate hepatic inflammation, apoptosis and necrosis of liver cells, chollestasis and fibrosis. Many immune system abnormalities have been associated with cirrhosis [2]. Most acute and chronic liver diseases are characterized by inflammation processes with enhanced expression of various pro- and anti- inflammatory cytokines in the liver [3]. In general, play an important role in host defense mechanism, and it is only under certain conditions that they may mediate deleterious results and contribute to the manifestations of tissue injury [4]. Spontaneous bacterial peritonitis (SBP) is an infectious disease specific to liver cirrhosis patients. Because inflammatory and immune reactions are altered by hepatic cirrhosis, the efficacy of innate reactions is limited [5]. SBP is associated with an important production of inflammatory mediators [6]
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