The effect of variceal bleeding on T-cell subsets in patients with cirrhosis

Maria Lagadinou,Dimitris Velissaris,Charalambos Gogos,Marina Karakantza

doi:10.7243/2055-088x-5-1

Abstract

Abstract Aim: Variceal bleeding may lead to infectious complications in patients with liver failure. The aim of the present study was to investigate the effect of variceal bleeding on T-cell subsets of patients with

Highlights

Acute variceal bleeding is one of the major causes of death in cirrhotic patients
The absolute number of T-cell subsets in group 1 vs group 2 were the following: Admission=CD3: 565±88 vs 507±197, CD56: 160±37 vs 95±14 (P
This may compromise immune response and may be associated with the observed increased in the frequency of infectious complications in cirrhotic patients, complicated with variceal bleeding

Summary

Introduction

Acute variceal bleeding is one of the major causes of death in cirrhotic patients. It is the major cause of upper gastrointestinal (GI) bleeding in cirrhotic patients, accounting for 70% of cases. Mortality during the first episode is estimated to 15–20%, but is higher in severe patients (Child Pugh C), at around 30%, whereas it is very low in patients with compensated cirrhosis [1]. Variceal bleeding may lead to infectious complications in patients with liver failure. Bacterial infections and/or endotoxaemia have been associated with failure to control variceal bleeding,more early variceal rebleeding, abnormalities in coagulation, vasodilatation of the systemic vasculature, and worsening liver function. There has been increased recognition that bacterial infections are involved in several pathophysiological abnormalities in cirrhosis [2]

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Conclusion