Acute toxicity determination of galenic and newgalenic phytosubstances from vaccinium vitis-idaea leaves

I. V. Kireyev,K. V. Tsemenko,O. M. Koshoviy

doi:10.24959/ubphj.19.221

Abstract

Acute toxicity determination of galenic and newgalenic phytosubstances from vaccinium vitis-idaea leaves

Highlights

The results of the study allow us to conclude the establishment of a medium-lethal dose of selected herbal substances is impossible and is beyond 15000 mg/kg, because intragastric administration in a maximum dose of toxicity class VI of 20000 mg/kg did not lead to death or the occurrence of pathological changes in the functional state of the organism of animals of both species
According to the generally accepted toxicological classification of substances, these phytoextracts belong to the V and toxicity classes – relatively harmless substances
We studied the acute toxicity of modified galenic and novogalenovy phytoextracts from the leaves of lingonberry ordinary with a single intragastric administration

Summary

National University of Pharmacy

At the stage of primary toxicological and pharmacological screening, the definition of the toxicity class of the investigated phytosubstantions, which have different qualitative and quantitative composition, is the first step of preclinical studies, the purpose of which is to obtain results on the safety of the test substance for health under conditions of short-term action. Aim. To study the modified phytosubstances acute toxicity from Vaccinium vitis-idaea leaves. The results of the study allow us to conclude the establishment of a medium-lethal dose of selected herbal substances is impossible and is beyond 15000 mg/kg, because intragastric administration in a maximum dose of toxicity class VI of 20000 mg/kg did not lead to death or the occurrence of pathological changes in the functional state of the organism of animals of both species. According to the generally accepted toxicological classification of substances, these phytoextracts belong to the V and toxicity classes – relatively harmless substances

Conclusions

Национальный фармацевтический университет

МАТЕРІАЛИ ТА МЕТОДИ

Продовження таблиці

ПЕРЕЛІК ВИКОРИСТАНИХ ДЖЕРЕЛ ІНФОРМАЦІЇ