Abstract
Study of hepatoprotective effect of a new herbal remedy “Hepatropin” on a model of hepatitis in rats caused by tuberculostatic medicines
Highlights
Treatment of patients with tuberculosis involves the use of anti-TB drugs (4-6) complex at the same time, which causes the development of severe toxic hepatitis
To evaluate the effectiveness of a new complex herbal medicine (CHM) “Hepatropin” in the form of granules in the experimental hepatitis conditions caused by tuberculostatic drugs
Study of hepatoprotective activity of a new CHM, “Hepatropin” granules on a model of hepatitis caused by intragastric administration of tuberculostatics mixture (Isoniazid 50 mg/kg, Rifampin 500 mg/kg, Pyrazynamide 1500 mg/kg) in the form of aqueous suspension for 14 days, in comparison with a reference medicine containing extracts of Fumaria officinalis and Silybum marianum fruits
Summary
Study of hepatoprotective effect of a new herbal remedy “Hepatropin” on a model of hepatitis in rats caused by tuberculostatic medicines. Treatment of patients with tuberculosis involves the use of anti-TB drugs (4-6) complex at the same time, which causes the development of severe toxic hepatitis. Severe toxic hepatitis occurs during the treatment of first-line drugs in 60 % of patients and 42.4 % when used of secondline drugs. In 10-28 % of patients the development of severe hepatitis requires the abolition of anti-TB chemotherapy. The existing conditions require the search and creation of new herbal drugs for the prevention and treatment of hepatitis caused by drugs. Aim. To evaluate the effectiveness of a new complex herbal medicine (CHM) “Hepatropin” in the form of granules in the experimental hepatitis conditions caused by tuberculostatic drugs
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