Abstract
Publisher Summary Modifications of plasma testosterone levels during corticotropin stimulation have been reported by several groups, in pathological conditions. This paper deals with the effect of adrenocorticotropic hormone ( ACTH ) administration on the plasma concentration of testosterone in normal men. In the present study, ACTH and cortisol decrease testosterone production. This fact is strengthened by the definite trend towards a rise of plasma interstitial cell stimulating hormone ( ICSH ) titers. As the changes of ICSH appeared after those of testosterone levels, the rise in plasma ICSH can be considered as a consequence of the fall in the plasma testosterone level. Testosterone levels in males decrease following administration of ACTH and cortisol, while the plasma ICSH titer increases. The latter phenomenon is considered secondary to the fall in plasma levels of testosterone. There are indications that ACTH influences plasma testosterone concentration independently of changes in cortisol secretion.
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