Abstract
The binding affinity between progesterone and corticosteroid-binding globulin (CBG or transcortin), exceeds that of cortisol-CBG complex in man and guinea pig. In human pregnancy, when the progesterone titre and the CBG concentration are high, the association between this steroid and CBG becomes significant. The distribution of cortisol and progesterone in protein bound and unbound fractions in human pregnancy have been reported. The present study is to find out whether binding of progesterone to CBG and to serum albumin supresses the progestational function. Biological inactivation of cortisol and corticosterone by complex formation with a protein has been reported from many laboratories. Inactivation was observed for deoxycorticosterone associated with albumin. The inactivity of progestin bound to unfractioned plasma protein was demonstrated; if such progestin was released by acid hydrolysis, it was active.
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