Abstract
Experimental solubility, acid-dissociation constants (pKa) and activity coefficient data have been compiled from the published pharmaceutical and chemical literature for neutral organic molecules and ionic species dissolved in anhydrous 1,2-propylene glycol. The compiled experimental data were transformed into molar solubility ratios, water-to-anhydrous propylene glycol (P) and gas-to-anhydrous propylene glycol (K) using standard thermodynamic relationships. The derived Abraham model correlations described the observed solubility and partition coefficient data of neutral organic compounds and ionic species to within 0.18 log units and 0.18 log units (or less), respectively.
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