Abstract
Earlier column chromatography was used for preparative purposes as well as for reaction control in organic synthesis. Column chromatography is an extremely tedious stage in any laboratory and can quickly become a point of congestion for any process lab. Flash chromatography is a technique developed as a modification of preparative column chromatography. This is an air pressure driven technique comprising of medium and short column chromatography, optimised for rapid separation of organic compounds. Modern flash chromatographic system consists of pre- packed plastic cartridges where in the solvent is pumped through the cartridge. By employing high pressure gas, the efficiency and speed of classical column chromatography can be increased. Flash chromatography is an easy & quick approach that is economical to preparative liquid chromatography. The content mentioned in this article mainly focuses on the various components, general principles, procedures and applications of flash chromatography.
Highlights
Earlier column chromatography was used for preparative purposes as well as for reaction control in organic synthesis
Flash chromatography is a technique developed as a modification of preparative column chromatography
Flash chromatography differs from other techniques in different aspects as follows: Principle: The eluent under pressurized gas is rapidly pushed through a short glass column a) It uses silica gel particles which pass through that is packed with an adsorbent of a well-defined particle size with a large inner diameter
Summary
J. Srikanth Sandesh*, Shyamala, Kurva Swapana, Sirra Balaiah, J V C Sharma. Joginapally. B. R Pharmacy College, Bhaskar nagar, Yenkapally (V ), Moinabad, Telangana 500075. Article Info: Received 23 January 2021; Accepted 26 February 2021 DOI: https://doi.org/10.32553/jbpr.v10i1.850 Corresponding author: J. Srikanth Sandesh Conflict of interest statement: No conflict of interest
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