Abstract
Rosuvastatin belongs to the category of statins, used in combination with calcium channel blockers, analgesicsand other class of cardiovascular disease drugs in the treatment of high cholesterol and related conditions to prevent cardiovascular diseases. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control, pharmacodynamic and pharmacokinetic studies. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumentalmethods which were developed and used for determination of Rosuvastatin in combined dosage forms have been reviewed. This review covers various analytical methods for estimation of Rosuvastatin calcium and Fenofibrate in combined dosage forms, such as spectrophotometry, derivative spectrophotometry and various highperformance liquid chromatographic (HPLC) methods that were published from 2010 to 2014. Key Words: Rosuvastatin, Fenofibrate, review, HPLC, Spectrophotometry
Published Version
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