A applicational analysis about the effect of Marine Injection on combined therapy of benign tracheobronchial stenosis

Abstract

Objective To preliminaryly explore the effect and adverse reaction of Marine Injection combined therapy through local spray in benign tracheobronchial stenosis. Methods 19 cases of bronchial tuberculosis were collected in our department. By assessing cough, shortness of breath and other symptoms, chest high-resolution CT (HRCT)of three-dimensional reconstruction, and length were observed by ultrafine bronchial stenosis. According to the pathogeny and types of stenosis, combined multiple intervention were sequentially adopted, and then Marine Injection was sprayed through one-off endoscopic spray tube. All the subjects were divided into the two groups, the higher concentration Marine injection(1 200 mg／mL)group was chosen with the condition of serious inflammation, edema, ulcer and necrosis, obvious local granulation tissue hyperplasia, severe scar stenosis, and the length of stenosis greater than 2 cm or the sectional area of stenosis less than 50% of the normal sectional area, otherwise the low concentration (600 mg／mL)group was chosen. The subjects were reexamined by clinical symptoms, high-resolution CT(HRCT)of three-dimensional reconstruction, and ultrafine bronchoscopy a week after the surgery to dynamically observe the local changes. Depending on the situation, the injection was sprayed once a week, adding up to 2-4 times. Followup visit lasted for 3 months, cough, expectoration or hemoptysis, and dyspnea were observed. Results 11 cases were effective fully, 17 cases were effective substantially, 7 cases were ineffective, the total effective rate was 80%(28／35). The overall complication rate was 42.8%(15／35), no deaths occurred. No complications related to local spra-ying of Marine were seen. Conclusion Local spray of Marine Injection may have preferable effect that inhibits scar formationand prevention airway restenosis. It is worth further study with a high security, precise clinic effect, easy oper-ation and etc. Key words: Marine; Bronchoscopy examination; Treatment; Intracavity; Benign tracheal stenosis