Abstract
Saffron ( Crocus sativus ) has demonstrated antispasmodic, antitussive, expectorant, hypolipidemic, memory enhancing, neuroprotective, antinociceptive, antidepressant, anxiolytic, anticonvulsant, and anticancer effects. Saffron stigma is commonly used as a culinary spice in Middle Eastern dishes. It has been used in traditional Persian medicine for cataracts, kidney stones, sexual dysfunction, stomachache, insomnia, and depression. Saffron may be beneficial for gingivitis, burning mouth syndrome, asthma, ischemic heart disease, dyslipidemia, diabetes, obesity, premenstrual syndrome, menopause, labor induction, male and female sexual dysfunction, fibromyalgia, stroke recovery, cognitive impairment, dementia, anxiety, OCD, depression, attention-deficit/hyperactivity disorder, and addiction disorders. This chapter examines some of the scientific research conducted on saffron, both alone and in combination formulas, for treating numerous health conditions. It summarizes results from several human studies of saffron’s use in treating ophthalmological, oral and dental, cardiovascular, cardiometabolic, genitourinary, musculoskeletal, and psychiatric disorders, among many others. Finally, the chapter presents a list of saffron’s active constituents, different Commonly Used Preparations and Dosage, and a section on “Safety and Precaution” that examines side effects, toxicity, and disease and drug interactions.
Published Version
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