5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping propertiesElectronic supplementary information (ESI) available: Tables of crystallographic data. See http://www.rsc.org/suppdata/p2/b2/b206909c/

Abstract

The nitrone DIPPMPO (5-diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide) was synthesised, isolated as hygroscopic crystals and its X-ray geometry was determined. The purification of DIPPMPO was easy, compared with that of DEPMPO (5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide) and its solutions in phosphate buffer were EPR silent. DIPPMPO exhibits all the advantages of DEPMPO for the spin-trapping of biological free radicals and thus DIPPMPO is a choice tool in this field.