Abstract
The variable temperature (298–179 K) 1H NMR spectra of N-substituted 2-benzazepines (compounds 2–7) correspond to two puckered mirror-image (enantiomorphic) conformations, with a single chair-to-chair interconversion barrier for the benzazepine ring of ca. 11 kcal mol−1 in CD2Cl2 solution. A similar interconversion was detected for 1,3,4,5-tetrahydro-N-methylbenzazepine (compound 1), of lower symmetry. The conformations of compounds 1–7 were assigned on the basis of the magnitude of 1H-1H vicinal coupling constants. The 1H and 13C NMR spectral assignments were determined by 1H–1H COSY, 1H–13C COSY, and NOESY experiments.
Published Version
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