3 - Synthesis of heterocycles via MCRs, using a name reaction in combination with another reaction

Abstract

Multicomponent reactions (MCRs) are convergent reactions, in which three or more commercially available or readily accessible starting materials react to form a product, where basically all or most of the atoms contribute to the newly formed product. Remarkably, a name reaction is a chemical reaction, which has reached to such status from different points of view, being named after its discoverers or developers. As far as the organic synthetic chemists concern an ideal reaction pathway for the synthesis of structurally complex substances should involve sequences in which stereocontrolled formation of multiple carbon–carbon bonds take place in a single step starting from simple commercially available or easily accessible compounds. In this chapter, we try to show the formation of various heterocycles via MCRs, using a name reaction such as Michael reaction, Mannich reaction, Knovenagel reaction, Aldol reaction, and Wittig reaction in combination with another reaction of name reactions.