1 - Introduction

Abstract

Chemistry as a fundamental and essential science in our daily life is facing a progressively accumulative demand in different disciplines, covering a broad range, as vast as, material sciences to life sciences. Organic chemistry is one of the subdisciplines of chemistry that studies the structure, properties, and reactions of organic compounds. They contain carbon in covalent bonding leading to synthesis of organic complex molecules, using commercially available or easily accessible starting materials. Rationally, an ideal organic synthesis should be straightaway, safe, facile, concise, selective, high yielding, being completed in short reaction time, environmentally benign, being commenced from commercially available or easily accessible starting materials and being performed with high diversity. Nowadays, among synthetic organic chemists community “MULTICOMPONERT REACTIONS” (MCRs) are considered as masterpieces of synthetic efficiency and state of art for designing an ideal synthetic pathway. The name reaction is a type of shorthand indication that evades the necessity to give a longer description of the features of a specific transformation of concern. Writing or saying the name reaction permits to bring to the mind of a well-informed reader or listener a conceivable idea about substrates, reagents, catalysts and reaction conditions, or possible events which may occur during the MCRs, thus gaining their detailed mechanistic pathways. In nature, asymmetric synthesis is a definite, thus, natural products provided via biosynthesis are optically pure. Even, those natural products bear several stereogenic centers, can be obtained as a single steroisomer from a natural source thus, frequently exhibit high biological potency. The high interest in MCRs lies not only in their promising and green features but also in their products biological potencies, frequently perceived for the products obtained, straightaway. Many MCR adducts exhibit prominent biological potencies even in their racemic forms, thus the attention to such compounds and their production in easier and less costly, approach have been increased, in last decades.