Abstract
Sesquiterpene lactones (SLs), a special class of naturally occurring biologically active natural products, have been isolated from numerous genera of Asteraceae (Compositae) family. Moreover, their availability has also been confirmed in certain other families of angiosperm. The wide structural diversity coupled with the potential pharmaceutical activities of these natural compounds against various diseases, such as anticancer, antimalarial, antimicrobial, antiviral, antiinflammatory, antitubercular, hepatoprotective, antiulcer, antioxidant, anti-HIV, antidiabetic, antipyretic, antidiarrheal, antidepressant, antihelminthic, antitrypanosomal, antifeedent activities, etc., have already attracted a great deal of attention from medicinal chemists at large. Certain SLs have been encountered as potential drugs for treating a number of various diseases. In the past few years, it has been confirmed through various reports that a majority of structurally diverse biologically potent SLs show potential as antimalarial agents. In the present chapter, a comprehensive account of SLs as antimalarial agents from the first reports to current reports is provided.
Published Version
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