Abstract
Sesquiterpene lactones (SLs), a special class of naturally occurring biologically active natural products, have been isolated from numerous genera of the Asteraceae (Compositae) family. Moreover, their availability has also been confirmed in certain other angiosperm families. Their wide structural diversity coupled with potential biological activities against various diseases such as anticancer, antimalarial, antimicrobial, antiviral, antiinflammatory, antitubercular, hepatoprotective, antiulcer, antioxidant, anti-HIV, antidiabetic, antipyretic, antidiarrheal, antidepressant, antihelminthic, antitrypanosomal, antifeedant activities, etc., has attracted a stir among the medicinal chemists around the globe. Some of them have been encountered as potential drugs for the treatment of various diseases. In recent years, it has been evidenced through various reports that majority of structurally diverse biologically potent SLs possess potential antidiabetic property. The present chapter offers a comprehensive account on the SLs and their semisynthetic analogues as potential antidiabetic agents reported so far.
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