Abstract
As specified in Chapter 19, malaria is an infectious disease transmitted via Anopheles mosquito in tropical countries. Since early civilization, natural products are being used as antimalarial drug. Keeping the benefits of natural remedies in minds, antimalarial phytoconstituents were screened and identified for further antimalarial drug discovery. In this chapter, authors discuss some newer potential antimalarial drug target proteins and some new source of phytochemicals that might have potential antimalarial property and drug lead. Authors performed receptor-based molecular docking of recent protein drug targets such as plasmepsin 2 (1LF2), HSP90 (3K60), PfATPase (1U5N), and Plasmodium orotidine 5-decarboxylase domain (3N3M) against the natural phytochemicals. The dock scores were in range of −6.1 to −10.7 for antimalarial targets. Some ligands showed better dock score than standard inhibitors of the respected proteins in the range of −6.9 to −10.7.
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