173 Causes of Death in Patients with Pancreatic Adenocarcinoma: A SEER-Based Study

Abstract

Abstract Aim To identify the commonest causes of non-cancer mortality in patients with PAC and compare their mortality risk with the general population. Method This population-based study analyzed data of PAC patients registered in the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016. Patients were followed up until 2016.We studied cancer and non-cancer causes of death and investigated their possible association with age, sex, race, tumor stage at presentation, and treatment modality; each according to the time interval from diagnosis during which death events occurred (intervals included < 1 year, 1–5 years, 5–10 years, and > 10 years after diagnosis).We estimated the standardized mortality ratio (SMR) with the 95% confidence interval (CI) for each mortality cause in each time interval. Analysis was conducted using SEER*Stat software version 8.3.9. Result A total of 67,694 PAC patients included in the analysis; of these patients, 64,347 (95.06%) died during the follow-up period. Most deaths occurred due to cancers (61,685; 95.86% of deaths), while non-cancer mortality causes represented only 4.14%.The commonest causes of non-cancer mortality were heart diseases (SMR = 2.79;95%CI,2.6–2.98),cerebrovascular diseases (SMR = 3.11;95% CI, 2.71–3.56), and septicemia (SMR = 8.2;95%CI,6.9–9.68).PAC patients had a higher mortality risk than the general population for all studied mortality causes except Alzheimer's disease (SMR = 0.5;95% CI, 0.3–0.78) and homicide and legal intervention (SMR = 2.29; 95%CI, 0.47–6.68). Conclusions About 96% of PAC patients' deaths are due to cancers. While the dominant non-cancer causes of death in these patients include heart diseases, cerebrovascular diseases, and septicemia, with a higher risk of mortality for most non-cancer causes than the general population.