Abstract
Brain is the most complex organ in human body. The prevalence of CNS diseases and their associated secondary diseases has become the growing threat and huge disease burden to the global society. Most medications in treating brain diseases have failed to yield significant therapeutic outcomes because of the impermeable membrane barriers lying between the brain and the circulation system, the blood-brain barrier (BBB). As a result, the brain drug delivery imposes a global challenge in the development of more effective CNS medications.
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