15 - Nanomaterials for skin repair and regeneration

Abstract

kin, the first line of defense for the human body that is exposed to external stimuli is susceptible to various kinds of injuries and damages and also plays a crucial protective role against wounds and damage. The goal of regenerative medicine is to restore or establish the normal function of human cells by replacing or “regenerating” human cells, tissues, or organs. Most of the regenerative medicine approaches for skin currently facing some major restrictions including lack of availability of proper biomaterials, improper/ineffective cell growth, unstable support of growth factors, lack of techniques for physiological architectures and essential responses by the physiological system. Moreover, incompetence to control cellular functions and suitable detection of biomolecular and biosensors are considered as add on to the current limitations in this field. Nanomedicine, a potent & promising outcome of Nanotechnology, already created a milestone in the field of heath and clinical research. The unique features of nanomaterials like small size, high cellular permeability, capacity of cell targeting and superior cellular acceptability enable nano medicines as an effective tool to address the limitations of regenerative medicine. This chapter is primarily focused to summarize the potential scope, challenges, and diverse application of various nanomaterials in skin wound healing, skin regeneration and rejuvenation of skin tissue.