Abstract
Silicon-substituted hydroxyapatite (Si-HA) is considered an indispensable player of the bone repair and regeneration field because of its comparatively enhanced biological activity as well as beneficial role in the early bone developmental processes than HA alone. This chapter shows a review of importance of silicon (Si) in human and its substitutional influence on HA lattice structure as well as how this substitution effects the solubility, porosity, surface charge, and crystalline properties of HA. In addition, this chapter also includes different synthesis methods of Si-HA as well as different techniques being used for its characterization. It also sheds light on Si-HA's usage as coating material on different metals to improve their properties and some important applications of Si-HA granules in medicine industry to treat different orthopedic-related problems. Finally, some important reported in vitro and in vivo studies to highlight Si-HA's biocompatibility and biological activity are discussed.
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